Resumen de A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors
Carolina Vicente Dueñas, Isabel Romero Camarero, Inés González Herrero, Esther Alonso Escudero, Fernando Abollo Jiménez, Xiaoxu Jiang, Norma Gutiérrez Gutiérrez, Alberto Orfao, Nieves Marín, Luisa María Villar Guimerans, M Criado, Belén Pintado Sanjuanbenito, Teresa Flores Ruano, Diego Alonso López, Rafael Jiménez Fernández, Javier de las Rivas Sanz, Francisco García Criado, María Begoña García Cenador, Izidore S. Lossos, César Cobaleda Hernández, Isidro Sánchez García
Transgenic expression of the MafB oncogene in haematopoietic stem/progenitor cells induces plasma cell neoplasia reminiscent of human multiple myeloma and suggests DNA methylation as cause of malignant transformation.
