Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis

• Alexander J Laarman ^[3] ; Gerdien Mijnheer ^[3] ; Joe M Mootz ^[1] ; Willemien J M van Rooijen ^[3] ; Maartje Ruyken ^[3] ; Cheryl L Malone ^[1] ; Erik C Heezius ^[3] ; Richard Ward ^[2] ; Graeme Milligan ^[2] ; Jos A G van Strijp ^[3] ; Carla J C de Haas ^[3] ; Alexander R Horswill ^[1] ; Kok P M van Kessel ^[3] ; Suzan H M Rooijakkers ^[3]
  1. [1] University of Iowa

     University of Iowa

     City of Iowa City, Estados Unidos

     
  2. [2] University of Glasgow

     University of Glasgow

     Reino Unido

     
  3. [3] Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands

  Mostrar afiliaciones +
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 17, 2012, págs. 3607-3619
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Neutrophil activation and recruitment to the site of infection are critical for host immunity. In humans, the cysteine protease Staphopain A of the pathogen S. aureus blocks this process by cleaving the chemokine receptor CXCR2.