A stomatin dimer modulates the activity of acid-sensing ion channels

• Janko Brand ^[2] ; Ewan St J Smith ^[1] ; David Schwefel ^[3] ; Liudmila Lapatsina ^[1] ; Kate Poole ^[1] ; Damir Omerbašić ^[1] ; Alexey Kozlenkov ^[1] ; Joachim Behlke ^[3] ; Gary R Lewin ^[1] ; Oliver Daumke ^[4]
  1. [1] Max Delbrück Center for Molecular Medicine

     Max Delbrück Center for Molecular Medicine

     Berlin, Stadt, Alemania

     
  2. [2] Max-Delbrück Center for Molecular Medicine, Crystallography Department, Berlin, Germany; Freie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany
  3. [3] Max-Delbrück Center for Molecular Medicine, Crystallography Department, Berlin, Germany
  4. [4] Max-Delbrück Center for Molecular Medicine, Crystallography Department, Berlin, Germany; Institute of Medical Physics and Biophysics, Charité, Berlin, Germany

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 17, 2012, págs. 3635-3646
• Idioma: inglés
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  • Stomatins govern membrane trafficking and ion channel activity. The banana-shaped stomatin-domain dimmers oligomerize into a cylindrical structure. A dynamic hydrophobic pocket at the concave side of the dimer mediates repression of acid-sensing ion channel 3 (ASIC3) activity.