Resumen de The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation

Florencia Cano, Helen Bye, L. M. Duncan, Karine Buchet-Poyau, Marc Billaud, Mark R Wills, Paul J. Lehner

• The novel RNA-binding E3 ubiquitin ligase MEX-3C targets the mRNA of MHC-I gene HLA-A2 for degradation in a RING-dependent manner. Depletion of MEX-3C in NK cells leads to reduced killing of target cells.