Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P2 and PI(5)P

• Yanling Zhang ; Amber J McCartney ^[1] ; Sergey N Zolov ^[1] ; Cole J Ferguson ^[1] ; Miriam H Meisler ^[1] ; Michael A Sutton ^[1] ; Lois S Weisman ^[1]
  1. [1] University of Michigan–Ann Arbor

     University of Michigan–Ann Arbor

     City of Ann Arbor, Estados Unidos

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 16, 2012, págs. 3442-3456
• Idioma: inglés
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• Resumen

  • Mice deficient for VAC14, a scaffolding protein required for PIP2 biosynthesis and linked to human neuropathies, show increased postsynaptic function due to altered AMPA receptor trafficking.