Resumen de Alternating access mechanism in the POT family of oligopeptide transporters

Nicolae Solcan, Jane Kwok, Philip W. Fowler, Alexander D. Cameron, David Drew, So Iwata, Simon Newstead

• Proton-dependent oligopeptide transporters are required for the uptake of diet-derived peptides in all kingdoms of life. The crystal structure of a bacterial transporter in the inward open conformation, together with a published structure in an occluded conformation, reveals the peptide transport mechanism.