Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

• Anitha Suram ^[3] ; Jessica Kaplunov ^[4] ; Priyanka L Patel ^[3] ; Haihe Ruan ^[3] ; Aurora Cerutti ^[1] ; Virginia Boccardi ^[3] ; Marzia Fumagalli ^[1] ; Raffaella Di Micco ^[1] ; Neena Mirani ^[5] ; Resham Lal Gurung ^[2] ; Manoor Prakash Hande ^[2] ; Fabrizio d'Adda di Fagagna ^[6] ; Utz Herbig ^[7]
  1. [1] FIRC Institute of Molecular Oncology

     FIRC Institute of Molecular Oncology

     Milán, Italia

     
  2. [2] National University of Singapore

     National University of Singapore

     Singapur

     
  3. [3] New Jersey Medical School-University Hospital Cancer Center, UMDNJ-New Jersey Medical School, Newark, NJ, USA
  4. [4] Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, NJ, USA
  5. [5] Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, Newark, NJ, USA
  6. [6] IFOM Foundation—FIRC Institute of Molecular Oncology Foundation, Milan, Italy; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy
  7. [7] New Jersey Medical School-University Hospital Cancer Center, UMDNJ-New Jersey Medical School, Newark, NJ, USA; Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, NJ, USA

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 13, 2012, págs. 2839-2851
• Idioma: inglés
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• Resumen

  • This study offers a novel view on the role of telomere attrition in human tumours, providing evidence for tumour suppressor activity resulting from telomere dysfunction-induced DNA damage responses.