The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress

• Manel Joaquin ^[1] ; Albert Gubern ^[1] ; Daniel González-Nuñez ^[1] ; E Josué Ruiz ^[2] ; Isabel Ferreiro ^[1] ; Eulalia de Nadal ^[1] ; Angel R Nebreda ^[3] ; Francesc Posas ^[1]
  1. [1] Universitat Pompeu Fabra

     Universitat Pompeu Fabra

     Barcelona, España

     
  2. [2] Signalling and Cell Cycle Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain
  3. [3] Signalling and Cell Cycle Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA) and Signalling and Cell Cycle Laboratory, Institute for Research in Biomedicine, Barcelona, Spain

  Mostrar afiliaciones +
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 13, 2012, págs. 2952-2964
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • The stress-activated protein kinase p38 phosphorylates p57/Kip2, resulting in enhanced CDK2 inhibition and a cell-cycle delay that helps cells to survive under stress.