3′-Processing and strand transfer catalysed by retroviral integrase in crystallo

• Stephen Hare ^[1] ; Goedele N Maertens ^[1] ; Peter Cherepanov ^[1]
  1. [1] Imperial College London

     Imperial College London

     Reino Unido

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 13, 2012, págs. 3020-3028
• Idioma: inglés
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• Resumen

  • Structures of a prototype integrase bound to viral cDNA offer insights into the early steps of retroviral host genome integration, and into the mechanisms of action of viral DNA strand transfer inhibitor (INSTI) drugs.