The location of splenic NKT cells favours their rapid activation by blood-borne antigen

• Patricia Barral ^[1] ; María Dolores Sánchez-Niño ^[1] ; Nico van Rooijen ^[2] ; Vincenzo Cerundolo ^[3] ; Facundo D Batista ^[1]
  1. [1] London Research Institute

     London Research Institute

     Reino Unido

     
  2. [2] VU University Amsterdam

     VU University Amsterdam

     Países Bajos

     
  3. [3] Weatherall Institute of Molecular Medicine

     Weatherall Institute of Molecular Medicine

     Oxford District, Reino Unido

     

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 10, 2012, págs. 2378-2390
• Idioma: inglés
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• Resumen

  • NKT cells play an important role in the immune responses to blood-borne infections. In vivo analysis shows that most NKT cells patrol the marginal zone and red pulp of the spleen. In response to bacterial antigens, NKT cells arrest and become activated to secrete cytokines.