O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

• Shalini Pathak ^[1] ; Vladimir S Borodkin ^[1] ; Osama Albarbarawi ^[1] ; David G Campbell ^[1] ; Adel Ibrahim ^[1] ; Daan MF van Aalten ^[1]
  1. [1] University of Dundee

     University of Dundee

     Reino Unido

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 6, 2012, págs. 1394-1404
• Idioma: inglés
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• Resumen

  • The protein kinase TAK1 plays an important role in pro-inflammatory cytokine signalling. Interleukin-1- and osmotic stress-induced O-GlcNAcylation of its regulatory subunit TAB1 is required for full TAK1 activation to induce downstream cytokine production, linking this protein modification to innate immunity signalling.