A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

• Demet Araç ^[1] ; Antony A Boucard ^[3] ; Marc F Bolliger ^[3] ; Jenna Nguyen ^[1] ; S Michael Soltis ^[2] ; Thomas C Südhof ^[1] ; Axel T Brunger ^[1]
  1. [1] Howard Hughes Medical Institute

     Howard Hughes Medical Institute

     Estados Unidos

     
  2. [2] Stanford University

     Stanford University

     Estados Unidos

     
  3. [3] Department of Molecular and Cellular Physiology, Stanford, CA, USA

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 6, 2012, págs. 1364-1378
• Idioma: inglés
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• Resumen

  • Crystallographic structures encompassing GPCR autoproteolytic sequences (GPS) delineate a novel conserved structural domain called GAIN, which is found in cell-adhesion GPCRs, polycystic kidney disease proteins conserved throughout evolution.