DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

• Michael Volkmar ^[1] ; Sarah Dedeurwaerder ^[1] ; Daniel A Cunha ^[1] ; Matladi N Ndlovu ^[1] ; Matthieu Defrance ^[1] ; Rachel Deplus ^[1] ; Emilie Calonne ^[1] ; Ute Volkmar ^[3] ; Mariana Igoillo-Esteve ^[1] ; Najib Naamane ^[1] ; Silvia Del Guerra ^[2] ; Matilde Masini ^[2] ; Marco Bugliani ^[2] ; Piero Marchetti ^[2] ; Miriam Cnop ^[1] ; Decio L Eizirik ^[1] ; François Fuks ^[1]
  1. [1] Université Libre de Bruxelles

     Université Libre de Bruxelles

     Arrondissement Brussel-Hoofdstad, Bélgica

     
  2. [2] University of Pisa

     University of Pisa

     Pisa, Italia

     
  3. [3] Department of Molecular Evolution, Institute for Cellular and Molecular Biology (IZMB), University of Bonn, Bonn, Germany

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 6, 2012, págs. 1405-1426
• Idioma: inglés
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• Resumen

  • The first genome-scale DNA methylation study on pancreatic islets from type 2 diabetic patients identifies disease-associated DNA methylation pattern that translate into aberrant gene expression in novel factors relevant for β-cell function and survival.