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A DR4: tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX

    1. [1] Department of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institute, The University of Colorado, Boulder, CO, USA
  • Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 5, 2012, págs. 1266-1278
  • Idioma: inglés
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  • Resumen
    • Depending on the context, cells either arrest or undergo apoptosis in response to p53 activation. Key mediators of both pathways are activated irrespective of the fate choice, but apoptotic cells selectively induce the DR4 death receptor pathway, caspase 8-mediated BID cleavage and activation of BAX.


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