NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression

• Nicola Reynolds ^[2] ; Mali Salmon-Divon ^[3] ; Heidi Dvinge ^[4] ; Antony Hynes-Allen ^[2] ; Gayan Balasooriya ^[2] ; Donna Leaford ^[2] ; Axel Behrens ^[1] ; Paul Bertone ^[5] ; Brian Hendrich ^[6]
  1. [1] London Research Institute

     London Research Institute

     Reino Unido

     
  2. [2] Wellcome Trust Centre for Stem Cell Research and MRC Centre for Stem Cell Biology and Regenerative Medicine, University of Cambridge, Cambridge, UK
  3. [3] EMBL European Bioinformatics Institute, Cambridge, UK; Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer, Israel
  4. [4] EMBL European Bioinformatics Institute, Cambridge, UK; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
  5. [5] EMBL European Bioinformatics Institute, Cambridge, UK; Genome Biology and Developmental Biology Units, EMBL, Heidelberg, Germany
  6. [6] Wellcome Trust Centre for Stem Cell Research and MRC Centre for Stem Cell Biology and Regenerative Medicine, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 3, 2011, págs. 593-605
• Idioma: inglés
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  • The NURD and Polycomb complexes PRC1 and PRC2 have been implicated in stem cell differentiation although their molecular roles are unclear. This study identifies a common set of genes that are sequentially regulated by these complexes, the NURD complex deacetylates H3K27 as a prerequisite for subsequent methylation by PRC2.