Coreceptor gene imprinting governs thymocyte lineage fate

• Stanley Adoro ^[5] ; Thomas McCaughtry ^[1] ; Batu Erman ^[2] ; Amala Alag ^[1] ; François Van Laethem ^[1] ; Jung-Hyun Park ^[1] ; Xuguang Tai ^[1] ; Motoko Kimura ^[1] ; Lie Wang ; Alex Grinberg ^[3] ; Masato Kubo ^[4] ; Remy Bosselut ^[1] ; Paul Love ^[3] ; Alfred Singer ^[1]
  1. [1] National Institutes of Health

     National Institutes of Health

     Estados Unidos

     
  2. [2] Sabancı University

     Sabancı University

     Turquía

     
  3. [3] National Institute of Child Health and Human Development

     National Institute of Child Health and Human Development

     Estados Unidos

     
  4. [4] Tokyo University of Science

     Tokyo University of Science

     Japón

     
  5. [5] Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 2, 2011, págs. 366-377
• Idioma: inglés
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• Resumen

  • Double-positive (CD4+CD8+) thymocytes differentiate into CD4+ helper T cells and CD8+ cytotoxic T cells. A knock-in approach replacing CD8-coding sequences with CD4 cDNA shows that it is the expression kinetics of CD8, and not the identity of the coreceptor, that governs thymocyte-lineage fate.