Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin

• Gabriela Whelan ^[1] ; Emanuel Kreidl ^[2] ; Gordana Wutz ^[2] ; Alexander Egner ^[1] ; Jan-Michael Peters ^[2] ; Gregor Eichele ^[1]
  1. [1] Max Planck Institute for Biophysical Chemistry

     Max Planck Institute for Biophysical Chemistry

     Landkreis Göttingen, Alemania

     
  2. [2] Research Institute of Molecular Pathology

     Research Institute of Molecular Pathology

     Innere Stadt, Austria

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 1, 2011, págs. 71-82
• Idioma: inglés
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• Resumen

  • Genetic deletion of murine Esco2 (an acetylase known to establish cohesin during S-phase and genetically linked to Roberts syndrome) results in embryonic lethality that can be molecularly linked to novel and specific functions of Esco2 at pericentric heterochromatin.