The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization

• Claire T Friel ^[1] ; Jonathon Howard ^[1]
  1. [1] Max Planck Institute of Molecular Cell Biology and Genetics

     Max Planck Institute of Molecular Cell Biology and Genetics

     Kreisfreie Stadt Dresden, Alemania

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 19, 2011, págs. 3928-3939
• Idioma: inglés
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• Resumen

  • Most kinesins move directionally along microtubules, but MCAK instead depolymerizes them. This study analyses the ATPase cycle of MCAK, identifying unusual kinetic features that fit with its unconventional activity.