Resumen de Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas

Clare V. LeFave, Massimo Squatrito, Sandra Vorlova, Gina L. Rocco, Cameron Brennan, E. C. Holland, Ying-Xian Pan, Luca Cartegni

• This study reveals two alternative splicing events that contribute to the development of glioma. HnRNPH is shown to control production of a pro-survival splice variant of the death-domain adaptor protein IG20-MADD and the motility-enhancing isoform of the RON receptor tyrosine kinase.