A cluster of ribosome synthesis factors regulate pre-rRNA folding and 5.8S rRNA maturation by the Rat1 exonuclease

• Sander Granneman ^[1] ; Elisabeth Petfalski ^[1] ; David Tollervey ^[1]
  1. [1] Wellcome Trust Centre for Cell Biology and Centre for Systems Biology at Edinburgh, University of Edinburgh, Edinburgh, Scotland
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 19, 2011, págs. 4006-4019
• Idioma: inglés
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• Resumen

  • Ribosome biogenesis involves a number of pre-rRNA cleavage events. This study characterizes the pre-rRNA interaction sites of the ribosome synthesis factors Cic1, Erb1, Nop7, Nop12, Nop15 and Nop4 and the 5′-exonuclease Rat1 and their role in 5.8S rRNA processing.