Resumen de An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer

Pierre Barraud, Stephan Emmerth, Yukiko Shimada, Hans-Rudolf Hotz, Frédéric H.-T. Allain, Marc Bühler

• The Dicer ribonuclease Dcr1 plays an important role in the biogenesis of small regulatory RNAs. Surprisingly, RNA binding by the double-stranded RNA binding domain (dsRBD) is dispensable for Dcr1 function, while zinc coordination of the extended dsRBD is required for its nuclear localization and RNA silencing.