Resumen de The pore structure and gating mechanism of K2P channels

Paula L Piechotta, Markus Rapedius, Phillip J Stansfeld, Murali K Bollepalli, Gunter Erhlich, Isabelle Andres-Enguix, Hariolf Fritzenschaft, Niels Decher, Mark S. P. Sansom, Steven J. Tucker, Thomas Baukrowitz

• K2P potassium channels are important regulators of cellular excitability. This study reveals that in contrast to most other K+ channels the primary gating mechanism in the K2P channel TREK-1 does not involve opening and closure of the cytoplasmic bundle crossing, but takes place close to or within the selectivity filter.