Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture

• Florian Ingo Schmidt ^[2] ; Christopher Karl Ernst Bleck ^[1] ; Ari Helenius ^[2] ; Jason Mercer ^[2]
  1. [1] University of Basel

     University of Basel

     Basilea, Suiza

     
  2. [2] Institute of Biochemistry, ETH Zurich, Zurich, Switzerland
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 17, 2011, págs. 3647-3661
• Idioma: inglés
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• Resumen

  • Double membrane-bound vaccinia extracellular virions actively promote their own macropinocytosis. This, followed by acid-induced rupture of the outer membrane in endocytic vesicles, exposes the inner membrane for fusion with the endocytic membrane and release into the cytosol.