Regulation of TFEB and V-ATPases by mTORC1

• Samuel Peña-Llopis ^[2] ; Silvia Vega Rubin de Celis ; Jacob C Schwartz ^[1] ; Nicholas C Wolff ^[2] ; Tram Anh T Tran ^[2] ; Lihua Zou ^[3] ; Xian-Jin Xie ^[1] ; David R Corey ^[1] ; James Brugarolas ^[2]
  1. [1] University of Texas Southwestern Medical Center

     University of Texas Southwestern Medical Center

     Estados Unidos

     
  2. [2] Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine, Oncology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
  3. [3] Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 16, 2011, págs. 3242-3258
• Idioma: inglés
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• Resumen

  • TORC1 is a key regulator of cell growth in response to nutrients and acts at the surface of the late endosome. This study identifies V-ATPase genes as transcriptional targets of TORC1 and implicates the transcription factor TFEB as an important mediator of TORC1-dependent gene expression and TORC1-regulated endocytosis.