Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding

• Masayoshi Honda ^[1] ; Yusuke Okuno ^[2] ; Jungmin Yoo ^[3] ; Taekjip Ha ^[1] ; Maria Spies ^[1]
  1. [1] Howard Hughes Medical Institute

     Howard Hughes Medical Institute

     Estados Unidos

     
  2. [2] Department of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA
  3. [3] Department of Physics and Center for the Physics of Living Cells, University of Illinois Urbana-Champaign, Urbana, IL, USA

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 16, 2011, págs. 3368-3382
• Idioma: inglés
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• Resumen

  • The DNA recombination mediator and annealing factor RAD52 is a target of c-ABL activated in response to DNA damage. Engineering of recombinant tyrosine-phosphomimetic RAD52 facilitated studying the consequences of this phosphorylation.