PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution

• Yuwen Ke ^[1] ; Jae-Wan Huh ^[2] ; Ross Warrington ^[1] ; Bing Li ^[1] ; Nan Wu ^[1] ; Mei Leng ^[3] ; Junmei Zhang ^[2] ; Haydn L Ball ^[2] ; Hongtao Yu ^[1]
  1. [1] Howard Hughes Medical Institute

     Howard Hughes Medical Institute

     Estados Unidos

     
  2. [2] University of Texas Southwestern Medical Center

     University of Texas Southwestern Medical Center

     Estados Unidos

     
  3. [3] Baylor College of Medicine

     Baylor College of Medicine

     Estados Unidos

     

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 16, 2011, págs. 3309-3321
• Idioma: inglés
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• Resumen

  • The helicase proteins PICH and BLM localize to ultrafine DNA threads between separating sister chromatids. It now appears they cooperate to remove histones from these anaphase DNA bridges, to allow their stretching and unravelling without breakage.