Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission

• Jian Zhao ^[1] ; Tong Liu ^[1] ; Shaobo Jin ^[2] ; Xinming Wang ^[1] ; Mingqi Qu ^[1] ; Per Uhlén ^[3] ; Nikolay Tomilin ^[4] ; Oleg Shupliakov ^[4] ; Urban Lendahl ^[2] ; Monica Nistér ^[1]
  1. [1] Karolinska University Hospital

     Karolinska University Hospital

     Suecia

     
  2. [2] Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
  3. [3] Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
  4. [4] Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 14, 2011, págs. 2762-2778
• Idioma: inglés
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• Resumen

  • Mitochondrial morphology depends on the balance between fission and fusion events. This study identifies a receptor for the fission factor Drp1 within the mitochondrial outer membrane, which inhibits Drp1-mediated fission and activates fusion.