Reino Unido
GB.ENG.H4.31UC, Reino Unido
City of Minneapolis, Estados Unidos
Mammalian centrosomes separate prior to mitosis in a process involving Cdk1 and the kinesin Eg5. Dissection by chemical genetics reveals a Cdk1-independent alternative mechanism, in which Plk1 counteracts both centrosomal cohesion factors and Eg5-opposing cytoskeletal forces.
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