Histone variant macroH2A confers resistance to nuclear reprogramming

• Vincent Pasque ^[1] ; Astrid Gillich ^[2] ; Nigel Garrett ^[1] ; John B Gurdon ^[1]
  1. [1] Wellcome Trust/Cancer Research UK Gurdon Institute

     Wellcome Trust/Cancer Research UK Gurdon Institute

     Cambridge District, Reino Unido

     
  2. [2] Wellcome Trust Cancer Research UK Gurdon Institute, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 12, 2011, págs. 2373-2387
• Idioma: inglés
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• Resumen

  • Gurdon and collaborators report reversible X chromosome inactivation in epiblast stem cells (EpiSCs) that seems to be determined by macroH2A1 deposition. These findings are of rather general interest as they highlight the epigenetic state of repressed loci as determinant for reprogramming efficiency.