Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane

• Tamimount Mohammadi ^[2] ; Vincent van Dam ^[2] ; Robert Sijbrandi ^[2] ; Thierry Vernet ^[3] ; André Zapun ^[3] ; Ahmed Bouhss ^[4] ; Marlies Diepeveen-de Bruin ^[2] ; Martine Nguyen-Distèche ^[1] ; Ben de Kruijff ^[2] ; Eefjan Breukink ^[2]
  1. [1] University of Liège

     University of Liège

     Arrondissement de Liège, Bélgica

     
  2. [2] Department of Chemical Biology and Organic Chemistry, Institute of Biomembranes, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Padualaan, Utrecht, The Netherlands
  3. [3] Institut de Biologie Structurale Jean-Pierre Ebel (CEA/CNRS/UJF), Laboratoire d'Ingénierie des Macromolécules, Grenoble Cedex, France
  4. [4] Enveloppes Bactériennes et Antibiotiques, Institut de Biochimie et Biophysique Moléculaire et Cellulaire, UMR 8619 CNRS, Université Paris-Sud XI, Orsay Cedex, France

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 8, 2011, págs. 1425-1432
• Idioma: inglés
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• Resumen

  • This study identifies FtsW as the flippase that translocates lipid-linked peptidoglycan precursors across the cell membrane during bacterial cell wall synthesis.