STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

• Martin Muik ^[3] ; Marc Fahrner ^[3] ; Rainer Schindl ^[3] ; Peter Stathopulos ^[1] ; Irene Frischauf ^[3] ; Isabella Derler ^[3] ; Peter Plenk ^[3] ; Barbara Lackner ^[3] ; Klaus Groschner ^[2] ; Mitsuhiko Ikura ^[1] ; Christoph Romanin ^[3]
  1. [1] University of Toronto

     University of Toronto

     Canadá

     
  2. [2] University of Graz

     University of Graz

     Graz, Austria

     
  3. [3] Institute of Biophysics, University of Linz, Linz, Austria

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 9, 2011, págs. 1678-1689
• Idioma: inglés
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• Resumen

  • Upon depletion of ER calcium stores, STIM1 and ORAI1 associate and induce calcium release-activated calcium (CRAC) currents. This study reveals that STIM1 undergoes an intramolecular transition into an extended conformation that is involved in ORAI1 binding and activation.