TIM23-mediated insertion of transmembrane α-helices into the mitochondrial inner membrane

• Salomé Calado Botelho ^[1] ; Marie Österberg ^[1] ; Andreas S Reichert ^[2] ; Koji Yamano ^[3] ; Patrik Björkholm ^[1] ; Toshiya Endo ^[3] ; Gunnar von Heijne ^[4] ; Hyun Kim ^[5]
  1. [1] Stockholm University

     Stockholm University

     Suecia

     
  2. [2] Goethe University Frankfurt

     Goethe University Frankfurt

     Frankfurt, Alemania

     
  3. [3] Nagoya University

     Nagoya University

     Naka-ku, Japón

     
  4. [4] Department of Biochemistry and Biophysics, Center for Biomembrane Research, Stockholm University, Stockholm, Sweden; Science for Life Laboratory Stockholm University, Solna, Sweden
  5. [5] Department of Biochemistry and Biophysics, Center for Biomembrane Research, Stockholm University, Stockholm, Sweden; School of Biological Sciences, Seoul National University, Seoul, South Korea

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 6, 2011, págs. 1003-1011
• Idioma: inglés
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• Resumen

  • This comprehensive analysis of the sequence determinants for TIM23-mediated insertion of mitochondrial inner membrane proteins reveals strikingly different requirements for protein insertion into the mitochondrial inner membrane and the endoplasmic reticulum.