Small RNA-mediated regulation of iPS cell generation

• Zhonghan Li ^[2] ; Chao-Shun Yang ^[2] ; Katsuhiko Nakashima ^[1] ; Tariq M Rana ^[2]
  1. [1] University of Massachusetts Medical School

     University of Massachusetts Medical School

     City of Worcester, Estados Unidos

     
  2. [2] Program for RNA Biology, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 5, 2011, págs. 823-834
• Idioma: inglés
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• Resumen

  • The generation of induced pluripotent stem cells is limited by the low reprogramming efficiency of somatic cells. Here, three clusters of miRNAs are shown to enhance reprogramming efficiency by targeting the TGF-β and p53 pathways, which inhibit the process.