Maruf M.U. Ali, Tina Bagratuni, Emma L Davenport, Piotr R. Nowak, M. Cris. Silva-Santisteban, Anthea Hardcastle, Craig McAndrews, Martin G. Rowlands, G. J. Morgan, Wynne Aherne, Ian Collins, Faith E. Davies, Laurence H. Pearl
In the endoplasmic reticulum, unfolded proteins stimulate Ire1 autophosphorylation and RNase activity. The crystal structure of the dephosphorylated kinase/RNase domain of human Ire1 bound to ADP provides insight into the autophosphorylation reaction.
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