Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells

• Diana M Vallejo ^[1] ; Esther Caparros ^[1] ; Maria Dominguez ^[1]
  1. [1] Consejo Superior de Investigaciones Científicas

     Consejo Superior de Investigaciones Científicas

     Madrid, España

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 4, 2011, págs. 756-769
• Idioma: inglés
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• Resumen

  • A genetic screen in Drosophila uncovers miR-8 as an inhibitor of Notch-induced overgrowth, and identifies a conserved regulatory network comprising the Notch pathway, ZEB1 and this miRNA regulating metastasis and proliferation in flies and cancer cells. See also Brabletz et al in this issue.