Resumen de PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity

Yasuo Nakamura, Catherine L Wood, Andrew P Patton, Nadia Jaafari, Jeremy M. Henley, Jack Mellor, Jonathan G. Hanley

• Dendritic spine remodelling involves regulated actin dynamics and is essential for synaptic plasticity. The Arp2/3 inhibitor PICK1 is here shown to regulate spine size: inducing shrinkage during long-term depression.