Resumen de Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages
Carmen G Palii, Carolina Pérez, Zizhen Yao, Yi Cao, Fengtao Dai, Jerry Davison, Harold Atkins, David Allan, F. Jeffrey Dilworth, Robert Gentleman, Stephen J. Tapscott, Marjorie Brand
Expression of the basic helix-loop-helix transcription factor TAL1/SCL is required for erythrocyte differentiation; aberrant expression in lymphoid cells leads to oncogenic transformation. Here, global analysis of TAL1 binding in erythroid and malignant T cells identifies cell type specific functional interaction with the transcription factors RUNX and ETS1.
