ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

• Claudia Cosentino ^[1] ; Domenico Grieco ^[2] ; Vincenzo Costanzo ^[1]
  1. [1] London Research Institute

     London Research Institute

     Reino Unido

     
  2. [2] CEINGE Biotecnologie Avanzate and Faculty of Biotechnological Sciences DBPCM, University of Naples ‘Federico II', Naples, Italy
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 3, 2010, págs. 546-555
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • The DNA damage-induced ATM kinase is linked to the metabolic pentose phosphate pathway, thus boosting biosynthesis of nucleotide precursors required for DNA repair and stimulating generation of the anti-oxidant NADPH, which may explain neurological defects of ataxia telangiectasia patients lacking ATM function.