Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans

• Sabine Lagger ^[1] ; Dominique Meunier ^[1] ; Mario Mikula ^[1] ; Reinhard Brunmeir ^[1] ; Michaela Schlederer ^[1] ; Matthias Artaker ^[1] ; Oliver Pusch ^[1] ; Gerda Egger ^[1] ; Astrid Hagelkruys ^[1] ; Wolfgang Mikulits ^[1] ; Georg Weitzer ^[1] ; Ernst W Muellner ^[1] ; Martin Susani ^[1] ; Lukas Kenner ^[1] ; Christian Seiser ^[1]
  1. [1] Medical University of Vienna

     Medical University of Vienna

     Innere Stadt, Austria

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 29, Nº. 23, 2010, págs. 3992-4007
• Idioma: inglés
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• Resumen

  • Although histone deacetylases are generally known as pro-tumourigenic factors, loss of HDAC1 is here shown to promote proliferation and inhibit differentiation in a mouse teratoma model, at least partly via regulation of the transcription factor SNAIL1.