Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping

• James M Dewar ^[1] ; David Lydall ^[2]
  1. [1] Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle upon Tyne, Tyne-and-Wear, UK
  2. [2] Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle upon Tyne, Tyne-and-Wear, UK; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, Tyne-and-Wear, UK
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 29, Nº. 23, 2010, págs. 4020-4034
• Idioma: inglés
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• Resumen

  • In the absence of the telomere capping protein Cdc13, budding yeast telomeres erode, resulting in checkpoint arrest. This study shows that the helicase Pif1, known as a telomerase inhibitor, also has a direct role in the resection of uncapped telomeres, acting in parallel to the nuclease Exo1.