Resumen de Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check

Nam Ky Tonthat, Stefan T Arold, Brian F Pickering, Michael W Van Dyke, Shoudan Liang, Yue Li, Tushar K Beuria, William Margolin, Maria A. Schumacher

• Nucleoid occlusion (NO) restricts bacterial cell division to prevent chromosome guillotining in the cell midzone when replication or segregation is delayed. Structural work suggests that the NO factor SlmA (synthetic lethal with a defective Min system) interferes with formation of the cytokinetic Z-ring by altering associations between FtsZ protofilaments.