Visualizing the transfer-messenger RNA as the ribosome resumes translation

• Jie Fu ^[1] ; Yaser Hashem ^[2] ; Iwona Wower ^[3] ; Jianlin Lei ^[1] ; Hstau Y Liao ^[1] ; Christian Zwieb ^[4] ; Jacek Wower ^[3] ; Joachim Frank ^[1]
  1. [1] Columbia University

     Columbia University

     Estados Unidos

     
  2. [2] Howard Hughes Medical Institute

     Howard Hughes Medical Institute

     Estados Unidos

     
  3. [3] Auburn University

     Auburn University

     Estados Unidos

     
  4. [4] University of Texas Health Science Center at Tyler

     University of Texas Health Science Center at Tyler

     Estados Unidos

     

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 29, Nº. 22, 2010, págs. 3819-3825
• Idioma: inglés
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• Resumen

  • Bacterial ribosomes that are stalled on mRNAs lacking a stop codon can be rescued by a process called ‘transtranslation' that involves the ribonucleoprotein complex tmRNA–SmpB. This cryo-EM study, and the copublished study by Weis et al, reveal how translation on tmRNA is resumed