Transient receptor potential channels meet phosphoinositides

• Bernd Nilius ^[1] ; Grzegorz Owsianik ^[1] ; Thomas Voets ^[1]
  1. [1] KU Leuven

     KU Leuven

     Arrondissement Leuven, Bélgica

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 27, Nº. 21, 2008, págs. 2809-2816
• Idioma: inglés
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• Resumen

  • Transient receptor potential (TRP) cation channels are unique cellular sensors that are involved in multiple cellular functions, ranging from transduction of sensory signals to the regulation of Ca2+ and Mg2+ homoeostasis. Malfunctioning of TRP channels is now recognized as the cause of several hereditary and acquired human diseases. At the time of cloning of the first Drosophila TRP channel, a close connection between gating and phosphatidylinositol phosphates (PIPs) was already recognized. In this review, we summarize current knowledge about the mechanisms of interaction between TRP channels and PIPs, and discuss the possible functional implications of TRP–PIP interactions to human physiology and pathophysiology.