HBV Slow Maturation Process Leads to Infection

• Autores: Koichi Watashi
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 24, Nº. 8, 2016, págs. 597-599
• Idioma: inglés
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• Resumen

  • Initial hepatitis B virus (HBV) attachment occurs via heparan sulfate proteoglycans (HSPGs), which then trigger receptor-mediated internalization. Although HSPGs express in many tissues, HBV is destined for hepatotropic infection. A recent paper by Seitz et al. proposed that the slow viral maturation process plays a critical role in liver-specific distribution.