Sympathetic innervation of human muscle spindles

• Dina Radovanovic ^[3] ; Kevin Peikert ^[1] ; Mona Lindström ^[3] ; Fatima Pedrosa Domellöf ^[2]
  1. [1] Dresden University of Technology

     Dresden University of Technology

     Kreisfreie Stadt Dresden, Alemania

     
  2. [2] Umeå University

     Umeå University

     Suecia

     
  3. [3] 1 Department of Integrative Medical Biology, Section of Anatomy, Umeå University Umeå, Sweden

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• Localización: Journal of Anatomy, ISSN 0021-8782, Vol. 226, Nº. 6, 2015, págs. 542-548
• Idioma: inglés
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  • The aim of the present study was to investigate the presence of sympathetic innervation in human muscle spindles, using antibodies against neuropeptide Y (NPY), NPY receptors and tyrosine hydroxylase (TH). A total of 232 muscle spindles were immunohistochemically examined. NPY and NPY receptors were found on the intrafusal fibers, on the blood vessels supplying muscle spindles and on free nerve endings in the periaxial space. TH-immunoreactivity was present mainly in the spindle nerve and vessel. This is, to our knowledge, the first morphological study concerning the sympathetic innervation of the human muscle spindles. The results provide anatomical evidence for direct sympathetic innervation of the intrafusal fibers and show that sympathetic innervation is not restricted to the blood vessels supplying spindles. Knowledge about direct sympathetic innervation of the muscle spindle might expand our understanding of motor and proprioceptive dysfunction under stress conditions, for example, chronic muscle pain syndromes.