Host Resistance and Immune Aging

• Autores: Thilinie Bandaranayake, Albert C. Shaw
• Localización: Clinics in geriatric medicine, ISSN 0749-0690, Vol. 32, Nº. 3, 2016, págs. 415-432
• Idioma: inglés
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• Resumen

  • Human immune system aging results in impaired responses to pathogens or vaccines. In the innate immune system, which mediates the earliest pro-inflammatory responses to immunologic challenge, processes ranging from Toll-like Receptor function to Neutrophil Extracellular Trap formation are generally diminished in older adults. Dysregulated, enhanced basal inflammation with age reflecting activation by endogenous damage-associated ligands contributes to impaired innate immune responses. In the adaptive immune system, T and B cell subsets and function alter with age. The control of cytomegalovirus infection, particularly in the T lineage, plays a dominant role in the differentiation and diversity of the T cell compartment.