Recurrent wheezing and asthma after bocavirus bronchiolitis

• T. del Rosal ^[1] ; M.L. García-García ^[2] ; C. Calvo ^[2] ; F. Gozalo ^[2] ; F. Pozo ^[3] ; I. Casas ^[3]
  1. [1] Hospital Universitario La Paz

     Hospital Universitario La Paz

     Madrid, España

     
  2. [2] Hospital Severo Ochoa

     Hospital Severo Ochoa

     Madrid, España

     
  3. [3] National Center of Microbiology, Instituto de Salud Carlos III, Madrid

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• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 44, Nº. 5, 2016, págs. 410-414
• Idioma: inglés
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• Resumen

  • Background Human bocavirus (HBoV) was recently discovered and identified as an important cause of respiratory infection in young children. However, the relationship between HBoV-bronchiolitis and the development of recurrent wheezing has not yet been established.

    Objective We designed this study in order to describe the mid-term outcome, regarding the development of recurrent wheezing and asthma of HBoV-bronchiolitis patients and to compare it with RSV-bronchiolitis infants.

    Methods We studied 80 children (10 with HBoV and 70 with RSV infection), currently aged ≥4 years and previously hospitalised during the seasons 2004–2009 due to acute bronchiolitis. Epidemiological and clinical data were collected through structured clinical interviews at the follow-up visit. Spirometry and skin prick tests to common food and inhaled allergens were performed.

    Results All HBoV-patients developed recurrent wheezing and half of them had asthma at age 5–7 years. Almost 30% required hospital admission for recurrent wheezing. Asthma (odds ratio (OR)=1.28) and current asthma (OR=2.18) were significantly more frequent in children with HBoV-bronchiolitis than in RSV-bronchiolitis. FEV1 values were 99.2±4.8 in HBoV-group vs. 103±11 in RSV-group, p: 0.09. No differences were found with respect to allergic rhinitis, atopic dermatitis, food allergy, proportion of positive prick tests, and family history of atopy or asthma.

    Conclusions Severe HBoV-bronchiolitis in infancy was strongly associated with asthma at 5–7 years.