Posıtıve effect of platelet rich fibrin on osseointegration

Elif Öncü; Burak Bayram; Alpdogan Kantarci; Serap Gülsever; Emine-Elif Alaaddinoğlu

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Posıtıve effect of platelet rich fibrin on osseointegration

Elif Öncü ^[1] ; Burak Bayram ^[2] ; Alpdoğan Kantarcı ^[3] ; Serap Gülsever ^[2] ; Emine-Elif Alaaddinoğlu ^[2]
1. [1] Necmettin Erbakan University
  
  Necmettin Erbakan University
  
  Turquía
2. [2] Başkent University
  
  Başkent University
  
  Turquía
3. [3] Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA, USA
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Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 21, Nº. 5 (Septiembre), 2016
Idioma: inglés
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Resumen
- Leukocyte-platelet rich fibrin (L-PRF) is a second generation platelet concentrate clinically used to accelerate tissue healing and bone regeneration. Achieving reduced implant osseointegration time could provide immediate or early loading of implants. The aim of this study was to evaluate the L-PRF-induced osseointegration and bone-implant contact (BIC) in an experimental animal model.
  
  Twelve 4-month-old New Zealand white rabbits were used. Following general anesthesia, 3-5 mL of blood was obtained from the central artery in rabbit ear and L-PRF was prepared. Two implant cavities (5 mm long and 3 mm in diameter) were created in each tibia with a total of four cavities in each animal. Two of these cavities were selected and covered with PRF (test group). The remaining L-PRF was used to soak the implants placed into the L-PRF covered sockets. Other cavities were left as controls. In total, 48 implants were placed. Animals were sacrificed after two, three, or four weeks. Histological samples were obtained and peri-implant tissues were histomorphometrically evaluated for bone-to-implant contact and new bone formation.
  
  Histomorphometric analyses of the defects revealed that the L-PRF was detectable up to the second week. Application of L-PRF increased the rate and amount of new bone formation in the experimental group compared to the control group. Bone-to-implant contact was enhanced when the surface was pre-wetted with L-PRF (p<0.01).
  
  The results of this study demonstrated that L-PRF application may increases amount and rate of new bone formation during the early healing period and provides a faster osseointegration around implants.