Limited beneficial effects of piceatannol supplementation on obesity complications in the obese Zucker rat: gut microbiota, metabolic, endocrine, and cardiac aspects

Elisabeth Hijona Muruamendiaraz; Leixuri Aguirre López; Patricia Pérez Matute; María Jesús Villanueva Millán; A. Mosqueda Solis; Mounia Hasnaoui; Françoise Nepveu; Jean-michel Senard; Luis Bujanda Fernández de Piérola; Luis Aldamiz-Echevarria Azuara; Marta Llarena Fernández; F. Andrade; P. Perio; F. Leboulanger; L. Hijona; José M. Arbonés Mainar; María Puy Portillo Baquedano; Christian Carpéné

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Limited beneficial effects of piceatannol supplementation on obesity complications in the obese Zucker rat: gut microbiota, metabolic, endocrine, and cardiac aspects

E. Hijona ^[1] ; L. Aguirre ^[1] ; P. Pérez-Matute ^[2] ; M. J. Villanueva-Millán ^[2] ; A. Mosqueda-Solis ^[1] ; M. Hasnaoui ^[5] ; F. Nepveu ^[3] ; J. M. Senard ^[5] ; L. Bujanda ^[1] ; L. Aldámiz-Echevarría ^[6] ; M. Llarena ^[6] ; F. Andrade ^[6] ; P. Perio ^[3] ; F. Leboulanger ^[5] ; L. Hijona ^[1] ; J. M. Arbones-Mainar ^[4] ; M.P. Portillo ^[1] ; C. Carpéné ^[5]
1. [1] Universidad del País Vasco/Euskal Herriko Unibertsitatea
  
  Universidad del País Vasco/Euskal Herriko Unibertsitatea
  
  Leioa, España
2. [2] Centro de Investigación Biomédica de La Rioja
  
  Centro de Investigación Biomédica de La Rioja
  
  Logroño, España
3. [3] Université de Toulouse
  
  Université de Toulouse
  
  Arrondissement de Toulouse, Francia
4. [4] Instituto Aragonés de Ciencias de la Salud
  
  Instituto Aragonés de Ciencias de la Salud
  
  Zaragoza, España
5. [5] INSERM U1048, Institute of Metabolic and Cardiovascular Diseases (I2MC)
6. [6] Cruces University Hospital
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Localización: Journal of physiology and biochemistry, ISSN-e 1877-8755, ISSN 1138-7548, Vol. 72, Nº. 3, 2016, págs. 567-582
Idioma: inglés
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Resumen
- Resveratrol is beneficial in obese and diabetic rodents. However, its low bioavailability raises questions about its therapeutic relevance for treating or preventing obesity complications. In this context, many related natural polyphenols are being tested for their putative antidiabetic and anti-obesity effects. This prompted us to study the influence of piceatannol, a polyhydroxylated stilbene, on the prevention of obesity complications in Zucker obese rats. A 6-week supplementation was followed by the determination of various markers in plasma, liver, adipose tissue and heart, together with a large-scale analysis of gut microbiota composition. When given in doses of 15 or 45 mg/kg body weight/day, piceatannol did not reduce either hyperphagia or fat accumulation. It did not modify the profusion of the most abundant phyla in gut, though slight changes were observed in the abundance of several Lactobacillus, Clostridium, and Bacteroides species belonging to Firmicutes and Bacteroidetes. This was accompanied by a tendency to reduce plasma lipopolysaccharides by 30 %, and by a decrease of circulating non-esterified fatty acids, LDL-cholesterol, and lactate. While piceatannol tended to improve lipid handling, it did not mitigate hyperinsulinemia and cardiac hypertrophy. However, it increased cardiac expression of ephrin-B1, a membrane protein that contributes to maintaining cardiomyocyte architecture. Lastly, ascorbyl radical plasma levels and hydrogen peroxide release by adipose tissue were similar in control and treated groups. Thus, piceatannol did not exhibit strong slimming capacities but did limit several obesity complications.