New β-Lactamase Inhibitors in the Clinic

• Autores: Krisztina M. Papp-Wallace, Robert A. Bonomo
• Localización: Infectious disease clinics of North America, ISSN 0891-5520, Vol. 30, Nº. 2, 2016 (Ejemplar dedicado a: Antibiotic Resistance: Challenges and Opportunities), págs. 441-464
• Idioma: inglés
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• Resumen

  • Given the serious medical burden of β-lactamases, many approaches are being used identify candidate agents for β-lactamase inhibition. Here, we review two β-lactam-β-lactamase inhibitor (BL-BLI) combinations, ceftolozane-tazobactam and ceftazidime-avibactam that recently entered the clinic. In addition, we focus on BL-BLI combinations in preclinical development that have demonstrated activity in clinical isolates via susceptibility testing and/or in in vivo models of infection. We highlight only the BLIs that are able to reduce the Clinical Laboratory Standards Institute (CLSI) breakpoints for the BL partner into the susceptible range. Our analysis includes the primary literature, meeting abstracts, as well as the patent literature.